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Propel your COVID-19 research


T cells are the adaptive immune system’s first responders to any virus, circulating in the blood to detect and quickly multiply to attack the virus, often before symptoms appear. Adaptive Biotechnologies’ unique MIRA Technology and immunoSEQ Technology have enabled us to create a comprehensive view of the T-cell response to SARS-CoV-2 infection. This data has been made public as part of the ImmuneCODE™ Initiative to help propel drug, vaccine, and clinical trial research.

The immunoSEQ® T-MAP™ COVID offering provides tools for researchers to study the COVID-19 T-cell immune response, including detecting past SARS-CoV-2-specific immune response in research samples & the ability to track responses longitudinally.

With immunoSEQ T-MAP COVID researchers can:

  • Detect past SARS-CoV-2-specific T-cell immune response with a simple positive/negative result in research samples & track responses longitudinally.
  • Search our SARS-CoV-2-specific TCR database to determine if their samples show SARS-CoV-2-specific TCRs & the antigens to which these TCR responded.
  • Study the T-cell immune response for vaccine research across COVID-19 variants. Map across >160K SARS-CoV-2-specific antigen-TCR sequence-level data.
  • Dive into sequence, patient or population-level data. Determine TCR clones shared between cohorts & those that are public vs private clones.
Antigen TCR Sequence Level Data 3
SARS-CoV-2-specific antigen-TCR sequence-level data

Quantitative sequence-level data for TCR repertoires for SARS-CoV-2-specific antigens

Past Immune Response
Past SARS-CoV-2-specific immune response

Detect past SARS-CoV-2-specific immune response in research samples and track responses longitudinally

SARS CoV 2 Variants 3
Study the T-cell response for SARS-CoV-2 variants

Assess the T-cell immune response for vaccine research across SARS-CoV-2 variants

Recent publications

Learn more about the science behind the ImmuneCODE™ database in our first publication and, to discover initial COVID-19 data insights, read our pre-print publication.

Nolan et al.

A large-scale database of T-cell receptor beta (TCRβ) sequences and binding associations from natural and synthetic exposure to SARS-CoV-2
View Publication

Snyder et al.

Magnitude and Dynamics of the T-Cell Response to SARS-CoV-2 Infection at Both Individual and Population Levels
View Publication

End-to-end solution; from experimental design to publication-ready data

SARS-CoV-2-specific TCR repertoire sequences & antigen data
  • Validated TCR-antigen data from >150 MIRA experiments
  • Determine past T-cell immune response to SARS-CoV-2 with a simple positive/negative output
  • In vivo identified SARS-CoV-2-specific TCR sequences
  • TCR-Antigen sequence-level data with the PCR, bias-controlled, reproducible immunoSEQ® Assay
ImmunoSEQ T MAP Analyzer
Data analysis through the immunoSEQ® Analyzer or computational biology services
  • Explore SARS-CoV-2-specific TCR-Antigen sequence data in the immunoSEQ Analyzer
  • Compare your COVID-19 samples against our COVID-19 samples to identify public vs private clones
  • Computational Biology Services for COVID-19 data and Metadata analysis
ImmunoSEQ T MAP SequenceData
Comprehensive COVID-19 TCR-antigen sequence database
  • Providing you a comprehensive view of SARS-CoV-2-specific antigen and TCR level data
  • Database will constantly be updated with new findings and TCR-Antigen sequence data

T cells in COVID-19: understanding the immune response to COVID-19

Learn how the immunoSEQ Technology and immunoSEQ T-MAP COVID can be used to better understand the immune response to SARS-CoV-2 infection.

Recent publications

Check out the publications below to learn how researchers are propelling their COVID-19 research by leveraging immunoSEQ T-MAP COVID and the ImmuneCODE COVID-19 database

Sidhom et al.

Analysis of SARS-CoV-2 specific T-cell receptors in ImmuneCODE reveals cross-reactivity to immunodominant Influenza M1 epitope
View Publication

Gittleman et al.

Diagnosis and Tracking of Past SARS-CoV-2 Infection in a Large Study of Vo’, Italy Through T-Cell Receptor Sequencing
View Publication

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COVID-19 Applications

Learn how immunoSEQ® T-MAP™ COVID can help uncover the T-cell immune response in COVID-19.

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Access technical documents for getting started with the immunoSEQ® Service product, grant writing support, and FAQs.

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