COVID-19 Publication Review

Discovery Series  |  Infectious Disease

How well are vaccines holding up against SARS-CoV-2 variants?

As SARS-CoV-2 virus variants emerge, new questions in the worldwide pandemic response are also emerging: What protection do vaccines provide against SARS-CoV-2 variants in terms of infection and disease severity?

In a recent study of the Johnson & Johnson vaccine’s efficacy against variants, researchers used immunoSEQ® T-MAP COVID to show that, despite a diminished neutralizing antibody response, vaccine-induced T-cell targeting of SARS-CoV-2 antigens was largely unaffected by mutations in the new variants. The latest evidence on the highly infectious Omicron variant suggests that mutations do not affect 70-80% of previously identified antigen specific T-cell responses to SARS-CoV-2.

COVID-19 Publication Review

In our in-depth COVID-19 publication review, learn more about:

  • Detecting the virus and immune response
  • Understanding exposure and immunity
  • Vaccine and drug development
  • Variants and vaccines
  • COVID-19’s impact on autoimmune disease
  • COVID-19’s impact on oncology

Featured webinar:

Harlan Robins (Adaptive CSO) discusses the T-cell response to COVID-19, vaccination, and variants

The emergence of SARS-CoV-2 variants makes understanding the immune system’s interaction with the virus more crucial than ever because current or future variants have the potential to evade the vaccine-induced immune response. Watch the webinar on COVID-19 vaccine research presented by Harlan Robins, Adaptive’s Chief Scientific Officer, featuring a complete index of the topics and audience discussion.

Additional Resources

Understanding the T-cell response: SARS-CoV-2 variants and vaccine immune response

View the webinar with Harlan Robins on T-cell responses to SARS-CoV-2 variants and vaccination produced with Nature Research Custom Media.

Immunogenicity of AD26.COV2.S vaccine against sars-cov-2 variants in humans

Learn how T-MAP COVID is being used to assess the impact of variants on vaccine efficacy.

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Effects Of COVID-19 Across Organs And Systems In Healthy And Immunocompromised Individuals

July 2021

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T Cells Are Important: SARS-CoV-2 Variants & Vaccine Immune Response

June 2021

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Emerging Themes Around The T-Cell Response & COVID-19: A Look Back At Some Of Our Discussions At World Vaccine Congress 2021

May 2021

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immunoSEQ® T-MAP™ COVID: A Tool To Uncover And Monitor The T-Cell Response in COVID-19

February 2021

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Monitoring The Immune Response To SARS-CoV-2: The Importance Of T Cells

January 2021

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