Dedicated to identifying new talent in the immunosequencing field
Every quarter, Adaptive Biotechnologies selects one or more applicants for our Young Investigator Award to receive a grant of up to $10,000 to assist in their research.
Every quarter, Adaptive Biotechnologies selects one or more applicants for our Young Investigator Award to receive a grant of up to $10,000 to assist in their research.
Research Summary: Cardiac allograft vasculopathy (CAV) is the leading cause of mortality following heart transplantation. We will test the hypothesis that this pathology is caused by selected T cell clones expanding in the heart transplant. Our project aims to understand the immune mechanisms underlying this pathology by identifying the T cells clones, via TCR sequencing, inducing chronic rejection after cardiac transplantation in mice. This knowledge will be instrumental for the design of novel immune-based therapies to prevent or cure CAV in heart-transplanted patients.
Research Summary: Older adults bear the greatest burden of morbidity and mortality following influenza (flu) infection. Although it is well known that overall T cell receptor diversity decreases with age, previous studies have not fully addressed how the diversity of flu-specific T cells are affected. The aim of this study is to utilize the immunoSEQ platform to fully characterize the clonal diversity of responding cytotoxic CD8 T cells in the lungs of both young and aged mice throughout flu infection. This work is imperative to understand how flu-specific T-cell responses change with age. Results from this project will inform future work on how to better target the aged immune system and improve CD8 T-cell responses to flu infection to protect this vulnerable population from infectious disease mortality.
Research Summary: A highly diverse T-cell receptor (TCR) repertoire is a fundamental property of an effective immune system and allows protection against a broad range of pathogens and cancer. In the setting of allogeneic hematopoietic stem cell transplant (HCT), the recovery of a donor-derived diverse TCR repertoire plays a critical role in the development of immune tolerance, graft versus leukemia as well as preventing infections. Critical aspects of TCR repertoire recovery have not been sufficiently clarified in the post-transplant cyclophosphamide (PTCy) haplo-HCT setting. The aim of this study is to compare reconstitution of TCRβ repertoire after haplo-HCT and matched donor-HCT and to evaluate the impact of the newly reconstituted TCRβ spectrum in the two cohorts on incidence of infections, GVHD and disease relapse.
Johanna Grund
Department of Pathology, University Hospital Schleswig-Holstein, Campus Kiel, Germany
Frederique St-Pierre, M.D., C.M.,
Division of Hematology and Oncology, Northwestern University
Magalli Magnoumba Legnanga, PhD student,
Africa Health Research Institute
Asmae Gassa, MD,
University of Cologne
Eriomina Shahaj, PhD,
Fondazione IRCCS Instituto Nazionale Dei Tumori
Coco de Koning, PhD,
University Medical Center Utrecht
Braden Tarlow, MD, PhD,
Stanford University Medical Center
Rachel Ambler, PhD,
The Francis Crick Institute
Kellie Nunez, PhD,
Ochsner Health System
Amelie Jule, PHD
Boston Children’s Hospital
Andrew Gunderson, PhD
Providence Portland Medical Center
Sruthi Ravindranathan, PhD
Emory University
Ronald Paranal, MD
MD Anderson Cancer Center
Emilie Foord, PhD
Karolinska Institute
Hussein Abbas, MD, PhD
MD Anderson Cancer Center
Swadhinya Arjunaraja, PHD
Uniformed Services University of the Health Sciences
Rachel Howard PhD
Lee Moffitt Cancer Center
Heather McGee, MD, PhD
Icahn School of Medicine at Mount Sinai
Lucas Arruda, PHD
Karolinska Institute
Dr. Med. Filiz Oezkan
The Ohio State University
Roy Rabbie, MBCHB (HONS), M.SC., MRCP
Wellcome Trust Sanger Institute, Cambridge
Jessica Stokes
University of Arizona
Timothy Taxter, MD
Northwestern University
Kathryn Steel, PhD
Kings College London Instituiton
Clinton Yam, MBBS
MD Anderson Cancer Center
James Godfrey, MD
University of Chicago
Lauren Colbert, MD
MD Anderson Cancer Center
Sami Kanaan, PhD
Fred Hutchinson Cancer Research Center
Benson Ogunjimi, PhD
University of Antwerp
Tiago R. Matos, MD, MSC, PhD
Academic Medical Center, University of Amsterdam
Ruth J. Napier, PhD
Oregon Health Science University
Isha Pradhan, PhD
Allegheny Health Network
Boglarka Ujhazi, MS
University of South Florida
Koorosh Korfi, PhD
Queen Mary University, London
Amy O’Connel, MD, PhD
Boston Children’s Hospital
Kate Poropatich, MD
Northwestern University Medical School
Tin Wang
University of Washington
Shwetank, PhD
Pennsylvania State University College of Medicine
Esteban Arrieta-Bolanos, PhD
Institute For Experimental Cellular Therapy, Essen University Hospital
Letizia Amadori, PhD
Icahn School Of Medicine At Mount Sinai
Matteo Dugo, M. Sc.
Fondazione Irccs Istituto Nazionale Dei Tumori
Adhideb Ghosh, M. Sc.
University Zürich Hospital
Ashley Plant, MD
Dana Farber Cancer Institute, Children’s Hospital Boston
Swati Shree, MD
University Of Washington Medical Center
Andreas Agathangelidis, PhD
Istituto Scientifico San Raffaele
Sarah Baxter, MD, PhD
Seattle Children’s Hospital
Catherine W. Cai
Saint Louis University School of Medicine
Georg J. Furtmüller, MD
Istituto Scientifico San Raffaele
Thet Su Win, MD, PhD
Brigham and Women’s Hospital
Justin Drerup
University Of Texas Health Science Center At San Antonio
Alexandre Reuben
University Of Texas Md Anderson Cancer Center
Joseph Thome
Columbia University
Fransenio Clark, BS
University Of Massachusetts Medical School
Laura Cook, PhD
University Of British Columbia, Child And Family Research Institute
Mathias Stiller
German Cancer Consortium
Mélissa Mathieu
Centre De Recherche Du Chum, Institut Duccancer De Montréal
Amy Moran, PhD
Earle A Chiles Cancer Research Institute
Jillian Richmond, PhD
University Of Massachusetts Medical School
Spyros Chalkias
Beth Isreal Deaconess Medical Center
Iwona Konieczna
Northwestern University
Elisa Masat
University Pierre And Marie Curie, Inserm U974
Reeta Vanhanen
Haartman Institute, University Of Helsinki
Yves T. Falanga, PhD
University Of Massachusetts Medical School
Nicolas Gulati
The Rockefeller University
Kinjal Majumder
Washington University In St. Louis
Ioannis Politikos, MD
Beth Israel Deaconess Medical Center
Wade Iams, MD
Vanderbilt University Medical Center
Natalie Miller
University Of Washington School Of Medicine
Daniel Lowther
Yale University
David B. Page, PhD
Memorial Sloan-Kettering Cancer Center
Xiaoti Guo, PhD
North Shore-Lij Health System
Krithika Kodumudi, MD
Lee Moffitt Cancer Center
Vinay S Mahajan, MD, PhD
Center For Cancer Research, Massachusetts General Hospital
Catherine Meador
Vanderbilt University
Matthew Rausch, PhD
University Of Arizona College Of Medicine
Lauren Henderson, PhD
Boston Children’s Hospital
David Bernal, PhD
Universidad Nacional De Colombia
Kirstin Heutinck, PhD
Academic Medical Center Amsterdam
Jamie Lynn Harden, MD
The Rockefeller University
Alan Watson, PhD
University Of Pittsburgh
Sven Malchow, PhD
University Of Chicago, Department Of Pathology
Marta Pasikowska
King’s College London
Michela Bardini
Centro Ricerca Tettamanti University Of Milan Bicocca
Jennifer Sims, PhD
Columbia University Medical Center
Gaurav Gaiha, PhD
Ragon Institute Of Mgh, MIT & Harvard
Eric Allenspach, MD
Seattle Children’s Hospital
Taizo Nakano, MD
Children’s Hospital Colorado
Evaggelia Liaskou
University Of Birmingham, UK
Kyle K. Payne
Virginia Commonwealth University – Massey Cancer Center
Alison Smith
Tulane University
Patrick Hanley
Baylor College Of Medicine
Adaptive is dedicated to identifying new talent to help foster growth in the immunosequencing field. Every quarter, Adaptive Biotechnologies Corporation selects one or more applicants for our Young Investigator Award to receive a grant of up to $10,000 to use for sequencing to assist in his/her research in immunology.
Thank you for your interest in our Young Investigator Award program. The program supports post-doctoral fellows and pre-doctoral students pursuing exciting research projects in immunology and other related fields with potential implications towards advancement in immunology. Each quarter our goal is to select one or more qualifying applicants to receive a immunosequencing grant of up to $10,000 to assist with their research. The grant may be applied toward any of Adaptive’s immunoSEQ® Assay products. In addition, our expert scientific advisors will provide experimental design and data analysis consultation. If you have any questions about the application process or would like to discuss your project or experimental design with one of our Scientific Liaisons, please contact scientificservices@adaptivebiotech.com.
To apply for our Young Investigator Award, complete and submit the form along with a one-page research proposal.
Applications for grants and all granted services must be for research purposes only, not for any diagnostic purposes.
** It is expected that all applicants will write their application independently, with only limited assistance from their mentor
Proposals will be evaluated on: the innovative application of immunoSEQ Assays to the research concept, the soundness of the research design, and the value of the research to the field of immunology.
All grant determinations and interpretations of the Young Investigator Award program will be made in the sole and absolute discretion of Adaptive Biotechnologies Corporation. The grant program may be revoked or terminated at any time for any reason, even after a grant notification has been issued. Winners will be required to sign or acknowledge a written grant agreement with Adaptive Biotechnologies Corporation as a condition for using the granted services.
You may not be eligible to receive the grant if you work for an institution that purchases diagnostic services from Adaptive Biotechnologies or if offering you the grant is otherwise prohibited under applicable law, which determination will be made by Adaptive Biotechnologies in its sole and absolute discretion. This grant receives support that may result in a report to the CMS Open Payments website under the Physician Payments Sunshine Act. The supporting companies are required to report the amount of the grant, the names of physicians who are awarded this grant, and the names of their institutions. This information may appear on the Open Payments website. More information about the Sunshine Act and CMS Open Payments program can be found here.
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