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Where do you draw the line for minimal residual disease (MRD) determination?
As chemotherapeutic treatment of patients with hematopoietic malignancies was emerging during the second half of the 20th century it became important to develop measurements and milestones of treatment efficacy. For decades the milestone of “remission” has included microscopic examination of … Continue reading
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DNA Extractions Simplified with New Device from UW Spinout Company NanoFacture
Yesterday, Science Daily announced a cool new device that can extract human DNA with full genetic data in minutes. The device is box shaped and handheld, and can extract DNA from fluid samples. Now, extracting DNA can be as easy … Continue reading
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Tumor Immune Suppression May Facilitate Targeted Radiation Treatment for Pancreatic Cancer
Because pancreatic cancer is often diagnosed after it has spread to other organs, treatment through chemotherapy, surgery, and radiotherapy are generally ineffective. Five-year survival is estimated at less than 5%, with no significant improvements in therapy in recent decades. In a mouse model … Continue reading
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The Cancer Genome Atlas Research Network Reports New Findings In Two Deadly Cancers
This week, two papers by the Cancer Genome Atlas Project (TCGA) consortium characterized genomes and epigenomic landscapes of two cancers: endometrial carcinoma (Nature) and adult de-novo acute myeloid leukemia (New England Journal of Medicine). Both studies describe molecular subtypes of … Continue reading
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Assays Take Spotlight at Cancer Immunotherapy Meeting
Last week, the Cancer Immunotherapy Consortium (CIC) held its annual meeting in Washington, DC, entitled “Entering the Era of Combination Therapies: Practical Implementation.” The meeting was focused on the complexity of developing combination cancer immunotherapies in light of the … Continue reading
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Will Cancer Diagnostics be the First Application of ‘Precision Medicine’?
In the cancer field we have been at ‘war’ for more than 40 years – ever since the signing of the National Cancer Act in 1971 by President Richard Nixon. Yesterday the NY Times published a great article titled ‘Cancer … Continue reading
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DNA vs cDNA on the immunoSEQ Assay
One of the recurrent questions that we field is whether our assay is limited to genomic DNA (gDNA), or can also be applied to cDNA. The answer is a little bit complicated, so please bear with me. First, to be … Continue reading
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Supreme Court To Decide on Whether Genes Can Be Patented
This week, the Supreme Court is hearing oral arguments in a case, Association for Molecular Pathology v. Myriad Genetics, that will determine the legal validity of patents on genetic testing for BRCA-1 and BRCA-2. Genotype at these two loci is … Continue reading
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A Recap of the AACR Meeting Highlights
At the recent annual meeting of the American Association of Cancer Research (AACR) much attention was paid to new immunotherapeutic approaches to cancer based on harnessing a patient’s immune response to recognize and eliminate malignant cells. The immune system is … Continue reading
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British Scientists Develop an Entirely Synthetic Vaccine
Vaccines of the past have relied on live infectious viruses, making them dangerous to work with and unstable. Now, a group of British scientists (hailing from Oxford and Reading Universities, the Pirbright Institute, and the UK’s National synchotron facility, the … Continue reading
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